Detail
| LncRNA Name | ENST00000398460 |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioblastoma |
| ICD-0-3 | M9440/3 |
| Methods | Microarray, qPCR, Western blot, Luciferase reporter assay, etc |
| Sample | cell lines(U87, U251), glioblastoma tissues |
| Expression Pattern | down-regulation |
| Function Description | Taken together, these findings highlight a novel oncogenic function of circRNA in glioblastoma tumorigenesis. To validate these results, 6 circRNAs NR_002791, and ENST00000398460) were selected randomly for qRT-PCR analysis. The results indicated that the expression levels of the 6 lncRNAs and 6 circRNAs detected by qRT-PCR were consistent with those of the microarray assays (Fig. S2). (hsa_circ_0001162, hsa_circ_0006774, hsa_circ_0077232, hsa_circ_0006847, hsa_circ_0037751,and hsa_circ_0083682) and 6 lncRNAs (lnc-BET3L-2:1, NR_002734, NR_037144, NR_024442, NR_002791, and ENST00000398460) were selected randomly for qRT-PCR analysis. The results indicated that the expression levels of the 6 lncRNAs and 6 circRNAs detected by qRT-PCR wereconsistent with those of the microarray assays (Fig. S2) Microarray profiling of circRNA/lncRNA/mRNA in glioblastoma identifies circNT5E as an oncogenic circular RNA and a sponge of miR-422a. |
| Pubmed ID | 29967262 |
| Year | 2018 |
| Title | CircNT5E acts as a sponge of microRNA-427a to promote glioblastoma tumorigenesis. |
| External Links |
| Links for ENST00000398460 | GenBank HGNC lncrnadb Noncode |
| Links for glioblastoma | Omim Cosmic |
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