Detail
| LncRNA Name | AFAP1-AS1 |
| Synonyms | AFAP1-AS1, AFAP1-AS, AFAP1AS, LOC84740, MGC10981 |
| Region | GRCh38_4:7754090-7778928 Sequence |
| Ensembl | ENSG00000272620 |
| RefSeq | NR_026892 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | gallbladder cancer |
| ICD-0-3 | C23.9 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | GBC tissues, cell lines (NOZ, H69 ,GBC-SD and SGC-996) |
| Expression Pattern | up-regulated |
| Function Description | The expression levels of lncRNA AFAP1-AS1 were significantly elevated in GBC tissues and GBC cell lines. In addition, the expression level of lncRNA AFAP1-AS1 was significantly associated with tumor sizes and the higher expression of lncRNA AFAP1-AS1 was correlated with poor prognosis in GBC patients. Knockdown of LncRNA AFAP1-AS1 suppressed cell growth and invasion in NOZ and GBC-SD cells. Furthermore, we found that knockdown of LncRNA AFAP1-AS1 in GBC cells inhibited EMT by down-regulating the transcription factor Twist1 and Vimentin and up-regulated the E-cadherin. |
| Pubmed ID | 27810781 |
| Year | 2016 |
| Title | Overexpression of LncRNA AFAP1-AS1 predicts poor prognosis and promotes cells proliferation and invasion in gallbladder cancer. |
| External Links |
| Links for AFAP1-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for gallbladder cancer | Omim Cosmic |
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