Detail

Chr	chr14
start	49586580
end	49586878
lncRNA name	7SL
entrez id	6029
hgnc id	HGNC:10038
ensg id	ENSG00000276168
refseq id	NR_002715
methods	qPCR, Western blot, ChIP, Luciferase reporter assay etc.
regulated	differential expression
function description	In this study, we detected that over-expression of FOXP3 repressed the transcription of 7SL RNA and contributed to inhibiting tumor growth. Knock down of FOXP3 in MCF-10A normal mammary breast cells up-regulated the transcription of 7SL RNA. Chromatin Immuno-precipitation (ChIP) analysis showed that FOXP3 directly bound to the Forkhead/HNF-3 domain DNA binding sites (-789 to -795) relative to the transcription start site. Meanwhile, Luciferase analysis showed that FOXP3 repressed the full-length 7SL promoter activity, but this suppressive effect was reversed after mutation of the FOXP3 binding site. Further studies showed that FOXP3 promoted the expression of P53 at translational levels through repressing 7SL RNA.
pubmed id	26718402
year	2016
title	Tumor FOXP3 represses the expression of long noncoding RNA 7SL.
drug	X
circulating	X
survival	X