Detail

Chr	chr3
start	50337511
end	50338300
lncRNA name	ANRASSF1
entrez id	102060282
hgnc id	HGNC:49091
ensg id	ENSG00000281358
refseq id	NR_109831
methods	RNA-seq, qPCR, RNAi, Western blot, RIP, ChIP, Cell proliferation assay etc.
regulated	up-regulated
function description	ANRASSF1 endogenous expression is higher in breast and prostate tumor cell lines compared with non-tumor, and an opposite pattern is observed for RASSF1A. ANRASSF1 ectopic overexpression reduces RASSF1A abundance and increases the proliferation of HeLa cells, whereas ANRASSF1 silencing causes the opposite effects. These changes in ANRASSF1 levels do not affect the RASSF1C isoform abundance. ANRASSF1 overexpression causes a marked increase in both PRC2 occupancy and histone H3K27me3 repressive marks, specifically at the RASSF1A promoter region.
pubmed id	23990798
year	2013
title	The intronic long noncoding RNA ANRASSF1 recruits PRC2 to the RASSF1A promoter, reducing the expression of RASSF1A and increasing cell proliferation.
drug	V
circulating	X
survival	V