Detail

Chr	NA
start	NA
end	NA
lncRNA name	ARNILA
entrez id	NA
hgnc id	NA
ensg id	NA
refseq id	NA
methods	Microarray, qPCR, Luciferase reporter assay, Western blot, ChIP etc.
regulated	up-regulated
function description	We performed experiments with or without DHT treatment in three TNBC cell lines, and we identified an AR negatively induced lncRNA (ARNILA), which correlated with poor progression-free survival (PFS) in TNBC patients and promoted epithelial-mesenchymal transition (EMT), invasion and metastasis in vitro and in vivo. Subsequently, we demonstrated that ARNILA functioned as a competing endogenous RNA (ceRNA) for miR-204 to facilitate expression of its target gene Sox4, which is known to induce EMT and contribute to breast cancer progression, thereby promoting EMT, invasion and metastasis of TNBC. High ARNILA expression was correlated with poor PFS(HR, 2.72; 95%CI, 1.26?5.70; P = 0.012) in TNBC.
pubmed id	29844570
year	2018
title	An androgen receptor negatively induced long non-coding RNA ARNILA binding to miR-204 promotes the invasion and metastasis of triple-negative breast cancer.
drug	X
circulating	X
survival	V