Detail

Chr	chr16
start	11819829
end	11828845
lncRNA name	BCAR4
entrez id	400500
hgnc id	HGNC:22170
ensg id	ENSG00000262117
refseq id	NR_024049
methods	qPCR, Western blot etc.
regulated	up-regulated
function description	Multivariate analyses established high BCAR4 mRNA levels as an independent predictive factor for poor PFS after start of tamoxifen therapy for recurrent disease. BCAR4 may have clinical relevance for tumour aggressiveness and tamoxifen resistance. Our cell model suggests that BCAR4-positive breast tumours are driven by ERBB2/ERBB3 signalling. Patients with such tumours may benefit from ERBB-targeted therapy.
pubmed id	20859285
year	2010
title	Relevance of BCAR4 in tamoxifen resistance and tumour aggressiveness of human breast cancer.
drug	V
circulating	X
survival	V