Detail

Chr	chr16
start	11819829
end	11828845
lncRNA name	BCAR4
entrez id	400500
hgnc id	HGNC:22170
ensg id	ENSG00000262117
refseq id	NR_024049
methods	qPCR etc.
regulated	up-regulated
function description	Forced expression of BCAR4 in human ZR-75-1 and MCF7 breast cancer cells resulted in cell proliferation in the absence of estrogen and in the presence of various antiestrogens. Inhibition of estrogen receptor 1 (ESR1) expression with small interfering RNA (siRNA), implied that the BCAR4-induced mechanism of resistance is independent of ESR1. BCAR4 is a strong transforming gene causing estrogen-independent growth and antiestrogen resistance, and induces tumor formation in vivo. Due to its restricted expression, BCAR4 may be a good target for treating antiestrogen-resistant breast cancer.
pubmed id	21506106
year	2011
title	Characterization of BCAR4, a novel oncogene causing endocrine resistance in human breast cancer cells.
drug	V
circulating	X
survival	V