Detail

Chr	NA
start	NA
end	NA
lncRNA name	BORG
entrez id	NA
hgnc id	NA
ensg id	NA
refseq id	NA
methods	qPCR etc.
regulated	up-regulated
function description	Through in silico and biological analyses, we identifed a novel lncRNA, BMP/OP-Responsive Gene (BORG), whose expression directly correlates with aggressive breast cancer phenotypes, as well as with metastatic competence and disease recurrence in multiple clinical cohorts. Mechanistically, BORG elicits the metastatic outgrowth of latent breast cancer cells by promoting the localization and transcriptional repressive activity of TRIM28, which binds BORG and induces substantial alterations in carcinoma proliferation and survival. Moreover, inhibiting BORG expression in metastatic breast cancer cells impedes their metastatic colonization of the lungs of mice, implying that BORG acts as a novel driver of the genetic and epigenetic alterations that underlie the acquisition of metastatic and recurrent phenotypes by breast cancer cells.
pubmed id	28983112
year	2017
title	The lncRNA BORG Drives Breast Cancer Metastasis and Disease Recurrence
drug	X
circulating	V
survival	V