Detail

Chr	chr8
start	127207382
end	127219268
lncRNA name	CCAT1
entrez id	100507056
hgnc id	HGNC:45128
ensg id	ENSG00000247844
refseq id	NR_108049
methods	qPCR, Luciferase reporter assay, RIP
regulated	up-regulated
function description	CCAT1 was up-regulated and miR-148b was down-regulated in radioresistant breast cancer tissues compared with radiosensitive breast cancer tissues.CCAT1 down-regulation reduced colony formation rates and caspase3 activity in breast cancer cells under irradiation. Moreover, CCAT1 could negatively regulate miR-148b expression. Furthermore, overexpression of miR-148b suppressed colony survival fraction and caspase3 expression under irradiation in breast cancer cells, which was exacerbated by CCAT1 knockdown.
pubmed id	29024383
year	2017
title	Down-regulation of LncRNA CCAT1 enhances radiosensitivity via regulating miR-148b in breast cancer.
drug	X
circulating	X
survival	V