Detail

Chr	chr8
start	127400399
end	127402150
lncRNA name	CCAT2
entrez id	101805488
hgnc id	HGNC:47044
ensg id	ENSG00000280997
refseq id	NR_109834
methods	qPCR, RNAi, Western blot, Cell proliferation assay etc.
regulated	up-regulated
function description	The expression level of CCAT2 in breast cancer tissues was significantly increased. The expression level of CCAT2 in breast cancer without metastasis was decreased compared with breast cancer metastasis. Meanwhile, down-regulation of CCAT2 inhibited the proliferation, invasion and migration in breast cancer cells. Furthermore, down-regulation of CCAT2 caused breast cancer cells cycle arrested in G0/G1 phase and promoted cell apoptosis. Down-regulation of CCAT2 significantly down-regulated the protein expression levels of TGF-B, Smad2 and a-SMA in breast cancer cells.
pubmed id	28272713
year	2017
title	Long non-coding RNA CCAT2 promotes the breast cancer growth and metastasis by regulating TGF-B signaling pathway.
drug	X
circulating	X
survival	X