Detail

Chr	chr8
start	127400399
end	127402150
lncRNA name	CCAT2
entrez id	101805488
hgnc id	HGNC:47044
ensg id	ENSG00000280997
refseq id	NR_109834
methods	qPCR, Western blot, RIP, ChIP etc.
regulated	up-regulated
function description	Moreover, when CCAT2 silencing, the cell cycle relative protein CyclinD1, CyclinE1 and CDK4 expression were downregulated, but p15 was up-regulated in MCF7 and MDA-MB-231 cells.CCAT2 expression levels in tumor tissues were markedly increased than that in adjacent normal tissues. higher CCAT2 expression was closely correlated with shorter over survival (OS) time in patients. CCAT2 suppressed the p15 expression level via interacting with EZH2 in breast cancer cells. In vivo, the tumor growth was inhibited after knockdown of CCAT2.
pubmed id	28531944
year	2017
title	Upregulation of CCAT2 promotes cell proliferation by repressing the P15 in breast cancer.
drug	X
circulating	X
survival	V