Detail

Chr	chr12
start	69239537
end	69274358
lncRNA name	CPSF6
entrez id	NA
hgnc id	NA
ensg id	ENSG00000111605
refseq id	NA
methods	qPCR, Western blot etc.
regulated	up-regulated
function description	Aggressive breast cancer cells require CPSF6 for viability and tumorigenesis. CPSF6 and paraspeckles core proteins are associated with poor outcome in breast cancer. Prolactin hormone reprograms cells to suppress CPSF6 interaction with paraspeckles and ADAR1, A-I RNA editing machinery. CPSF6 and all core paraspeckles proteins to be overexpressed in human breast cancer cases and their expression to correlate with poor patient outcomes. the important role and contribution of CPFS6 to survival and tumor formation of aggressive breast cancer cells.
pubmed id	28673861
year	2017
title	CPSF6 is a Clinically Relevant Breast Cancer Vulnerability Target: Role of CPSF6 in Breast Cancer.
drug	X
circulating	X
survival	V