Detail

Chr	NA
start	NA
end	NA
lncRNA name	CR593775
entrez id	NA
hgnc id	NA
ensg id	NA
refseq id	NA
methods	microarray, qPCR, RNAi, Western blot etc.
regulated	up-regulated
function description	From these 127 DE lncRNAs, we selected the top 25 most significant genes for further validation and analysis (electronic supplementary material, table S2). For 23 out of 25 (92%) of the lncRNAs tested, quantitative real-time PCR (qRTPCR) on cDNA templates confirmed the microarray results. These results suggest that CR593775 is involved in mediating the downstream effects of oestrogen signalling on breast cancer cell proliferation, including possible interactions with mechanisms of DNA synthesis regulation. Cell cycle analysis in synchronized cells indicates that disruption of CR593775 expression did not affect cell cycle progression.
pubmed id	28003470
year	2016
title	Primate-specific oestrogen-responsive long non-coding RNAs regulate proliferation and viability of human breast cancer cells.
drug	X
circulating	X
survival	X