Detail

Chr	chr4
start	52712404
end	52720351
lncRNA name	DANCR
entrez id	57291
hgnc id	HGNC:28964
ensg id	ENSG00000226950
refseq id	NR_024031
methods	qPCR, Western blot, RIP, RNA pull-down assay, Cell proliferation assay etc.
regulated	down-regulated
function description	We also uncover ANCR is an important player in breast cancer progression and metastasis mainly through decreasing EZH2 stability. More specifically, we initially found that ANCR level was lower in breast cancer tissues and breast cancer cell lines, in contrast to their normal counterparts. We then demonstrated that knockdown of ANCR induced an EMT program and promoted cell migration and invasion in MCF10A (epithelial cells), whereas ectopic expression of ANCR repressed breast cancer cells migration and invasion.
pubmed id	27716745
year	2017
title	The degradation of EZH2 mediated by lncRNA ANCR attenuated the invasion and metastasis of breast cancer.
drug	X
circulating	X
survival	X