Detail

Chr	chr1
start	155078872
end	155087538
lncRNA name	EFNA3
entrez id	1944
hgnc id	HGNC:3223
ensg id	ENSG00000143590
refseq id	NA
methods	qPCR, RIP etc.
regulated	up-regulated
function description	We demonstrate that sustained expression of both Ephrin-A3 and novel EFNA3 lncRNAs increased the metastatic potential of human breast cancer cells, possibly by increasing the ability of tumor cells to extravasate from the blood vessels into surrounding tissue. In agreement, we found a strong correlation between high EFNA3 expression and shorter metastasis-free survival in breast cancer patients. hypoxia could contribute to metastatic spread of breast cancer via HIF-mediated induction ofEFNA3lncRNAs and subsequent Ephrin-A3 protein accumulation.
pubmed id	25023702
year	2014
title	EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination.
drug	X
circulating	X
survival	V