Detail

Chr	NA
start	NA
end	NA
lncRNA name	EPIC1
entrez id	NA
hgnc id	NA
ensg id	NA
refseq id	NA
methods	qPCR, Western blot, in vitro knockdown, RIP etc.
regulated	up-regulated
function description	Overexpression of EPIC1 is associated with poor prognosis in luminal B breast cancer patients and enhances tumor growth in vitro and in vivo. Mechanistically, EPIC1 promotes cell-cycle progression by interacting with MYC through EPIC1's 129-283 nt region. EPIC1 knockdown reduces the occupancy of MYC to its target genes (e.g., CDKN1A, CCNA2, CDC20, and CDC45). MYC depletion abolishes EPIC1's regulation of MYC target and luminal breast cancer tumorigenesis in vitro and in vivo.
pubmed id	29622465
year	2018
title	lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.
drug	X
circulating	X
survival	V