The Genomic Atlas of Breast Cancer — the non-coding theme
| Chr | NA |
| start | NA |
| end | NA |
| lncRNA name | ESRPS-AS |
| entrez id | NA |
| hgnc id | NA |
| ensg id | NA |
| refseq id | NA |
| methods | qPCR, RNA-seq, western blot etc. |
| regulated | up-regulated |
| function description | ESRPs were shown previously to have a dual role in carcinogenesis. Both gain and loss have been associated with poor prognosis in human cancers, but the mechanisms regulating expression are not known. Indepth analyses indicate that coordinate overexpression of Esrp2 and Esrp2-as inversely correlates with DNA methylation. Using the Kaplan¡§CMeier plotter survival analysis tool,we could confirm that high ESRP2 mRNA levels reduce the fraction of relapse-free survival, overall survival, and distant metastasis-free survival of breast cancer cases analyzed together or when cases were subdivided into breast cancer subtypes. |
| pubmed id | 28759043 |
| year | 2017 |
| title | Genome-wide screen for differentially methylated long noncoding RNAs identifies Esrp2 and lncRNA Esrp2-as regulated by enhancer DNA methylation with prognostic relevance for human breast cancer |
| drug | X |
| circulating | X |
| survival | V |
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