Detail

Chr	chr6
start	1605531
end	1606079
lncRNA name	FOXCUT
entrez id	101927703
hgnc id	HGNC:50650
ensg id	ENSG00000280916
refseq id	NR_125804
methods	qPCR, RNAi etc.
regulated	up-regulated
function description	The results showed that the expression of FOXCUT and FOXC1 were positively correlated. When the expression of FOXCUT was downregulated by small interfering RNA, the expression of FOXC1 was similarly reduced. Furthermore, in MDA-MB-231 and MDA-MB-468 breast cancer cells, knockdown of FOXCUT markedly inhibited cell proliferation and migration in vitro. In conclusion, FOXCUT lncRNA may be functionally involved in the tumor progression of BLBCs through the regulation of its paired mRNA, FOXC1, demonstrating that FOXCUT may serve as a novel biomarker and therapeutic target in BLBCs.
pubmed id	25516208
year	2014
title	Forkhead box C1 promoter upstream transcript, a novel long non-coding RNA, regulates proliferation and migration in basal-like breast cancer.
drug	X
circulating	X
survival	X