Detail

Chr	chr1
start	173863900
end	173868882
lncRNA name	GAS5
entrez id	60674
hgnc id	HGNC:16355
ensg id	ENSG00000234741
refseq id	NR_002578
methods	qPCR, RNAi etc.
regulated	down-regulated
function description	In this preclinical study, the consequences of decreased GAS5 expression for breast cancer cell survival following treatment with chemotherapeutic agents are addressed. GAS5 lncRNA promoted the apoptosis of triple-negative and oestrogen receptor-positive cells but only dual PI3K/mTOR inhibition was able to enhance GAS5 levels in all cell types. Reduced GAS5 expression attenuates apoptosis induction by classical chemotherapeutic agents in breast cancer cells, providing an explanation for the relationship between GAS5 expression and breast cancer patient prognosis.
pubmed id	24789445
year	2014
title	Regulation of apoptosis by long non-coding RNA GAS5 in breast cancer cells: implications for chemotherapy.
drug	X
circulating	X
survival	V