Detail

Chr	chr1
start	173863900
end	173868882
lncRNA name	GAS5
entrez id	60674
hgnc id	HGNC:16355
ensg id	ENSG00000234741
refseq id	NR_002578
methods	qPCR, RNAi, Western blot, Cell proliferation assay etc.
regulated	down-regulated
function description	Ten different lncRNAs were applied in this study, which was reported to be associated with Notch-1. The level of these ten lncRNAs in breast tumors and adjacent normal tissues were evaluated, which suggested that HOTAIR and MALAT1 increased most significantly, and LUNAR1 and GAS5 decreased most significantly. High level of Notch-1 provided a poor prognosis in breast cancer. Interference of Notch-1 significantly suppressed proliferation of T47D cell, and significantly increased the level of GAS5.
pubmed id	26550436
year	2015
title	Notch-1 promotes breast cancer cells proliferation by regulating LncRNA GAS5.
drug	X
circulating	X
survival	V