Detail

Chr	chr11
start	1995176
end	2001470
lncRNA name	H19
entrez id	283120
hgnc id	HGNC:4713
ensg id	ENSG00000130600
refseq id	NR_002196
methods	qPCR, ChIP etc.
regulated	differential expression
function description	Additionally, blocking ERa decreased H19 expression in the luminal progenitors and led to the development of smaller luminal colonies. We further showed that knocking down the H19 gene in the luminal progenitors significantly decreased the colony-forming potential of the luminal progenitors, and this phenotype could not be rescued by the addition of estrogen. Lastly, we explored the clinical relevance of the estrogen-H19 signaling axis in breast tumors and found that ERa(+) tumors exhibited a higher expression of H19 as compared with ERa(-) tumors and that H19 expression showed a positive correlation with ERa expression in those tumors.
pubmed id	25944846
year	2015
title	Estrogen regulates luminal progenitor cell differentiation through H19 gene expression.
drug	X
circulating	X
survival	X