Detail

Chr	chr11
start	1995176
end	2001470
lncRNA name	H19
entrez id	283120
hgnc id	HGNC:4713
ensg id	ENSG00000130600
refseq id	NR_002196
methods	qPCR, RNAi, Luciferase reporter assay, ISH etc.
regulated	up-regulated
function description	BCSCs express high levels of H19, and ectopic overexpression of H19 significantly promotes breast cancer cell clonogenicity, migration and mammosphere-forming ability. Conversely, silencing of H19 represses these BCSC properties. In concordance, knockdown of H19 markedly inhibits tumor growth and suppresses tumorigenesis in nude mice. Mechanistically, we found that H19 functions as a competing endogenous RNA to sponge miRNA let-7, leading to an increase in expression of a let-7 target, the core pluripotency factor LIN28, which is enriched in BCSC populations and breast patient samples.
pubmed id	28102845
year	2017
title	H19/let-7/LIN28 reciprocal negative regulatory circuit promotes breast cancer stem cell maintenance.
drug	X
circulating	X
survival	V