Detail

Chr	chr11
start	1995176
end	2001470
lncRNA name	H19
entrez id	283120
hgnc id	HGNC:4713
ensg id	ENSG00000130600
refseq id	NR_002196
methods	qPCR etc.
regulated	up-regulated
function description	In our study, we confirmed that the T variant of rs217727 was consistently associated with an increased risk of BC in the codominant model.Another previous study by Yang et al32 found that the rs217727 CT + TT genotypes were correlated with significantly increased gastric cancer risk (OR 1.32, 95% CI 1.01��C1.71), while in functional assay analysis, the rs217727 CT, TT, or CT + TT genotypes were found not to affect H19 mRNA expression levels compared with the CC genotype, suggesting the C/T mutation might potentially change translational efficiency and lead to a transformation in H19 structure, thereby influencing the function of H19.
pubmed id	28919786
year	2017
title	Genetic variants in long noncoding RNA H19 contribute to the risk of breast cancer in a southeast China Han population.
drug	X
circulating	X
survival	X