Detail

Chr	chr11
start	1995176
end	2001470
lncRNA name	H19
entrez id	283120
hgnc id	HGNC:4713
ensg id	ENSG00000130600
refseq id	NR_002196
methods	qPCR etc.
regulated	up-regulated
function description	Network analysis revealed the existence of five genes related with H19,including miR-103, miR-107, let-7, miR-29b-1, and Trx. In-vitro analysis showed that suppression of H19 using siRNA reduces sphere formation capacity in both HCC1934 and iCSCL10A cell lines.In clinical studies, H19 expression was associated with hormone negativity, tumor size, and nodal status.Patients with H19 expression had significantly poor disease-free survival (DFS) and overall survival(OS). The effect of H19 expression on prognosis was the most significant in triple-negative breast cancer compared to that in other subtypes.
pubmed id	29693231
year	2018
title	LncRNA H19 is associated with poor prognosis in breast cancer patients and promotes cancer stemness.
drug	X
circulating	X
survival	V