Detail

Chr	chr12
start	53962308
end	53974956
lncRNA name	HOTAIR
entrez id	100124700
hgnc id	HGNC:33510
ensg id	ENSG00000228630
refseq id	NR_003716
methods	microarray, qPCR, RNAi, ChIP, Luciferase reporter assay etc.
regulated	up-regulated
function description	Here, we investigated the role of Hotair in the scenario of epithelial-to-mesenchymal transition (EMT) and in the arising and maintenance of cancer stem cells (CSCs). We found that treatment with TGF-B1 resulted in increased Hotair expression and triggered the EMT program. Interestingly, ablation of Hotair expression by siRNA prevented the EMT program stimulated by TGF-B1, and also the colony-forming capacity of colon and breast cancer cells. Furthermore, we observed that the colon CSC subpopulation (CD133(+)/CD44(+)) presents much higher levels of Hotair when compared with the non-stem cell subpopulation.
pubmed id	24022994
year	2013
title	Brief report: The lincRNA Hotair is required for epithelial-to-mesenchymal transition and stemness maintenance of cancer cell lines.
drug	X
circulating	X
survival	X