Detail

Chr	chr12
start	53962308
end	53974956
lncRNA name	HOTAIR
entrez id	100124700
hgnc id	HGNC:33510
ensg id	ENSG00000228630
refseq id	NR_003716
methods	qPCR, RNAi, ChIP, Dual-luciferase reporter assay etc.
regulated	up-regulated
function description	Luciferase assay showed that HOTAIR promoter estrogen-response-elements (EREs) are induced by BPA and DES. Estrogen-receptors (ERs) and ER-coregulators such as MLL-histone methylases (MLL1 and MLL3) bind to the HOTAIR promoter EREs in the presence of BPA and DES, modify chromatin (histone methylation and acetylation) and lead to gene activation. Knockdown of ERs down-regulated the BPA and DES-induced expression of HOTAIR.
pubmed id	24533973
year	2014
title	Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo.
drug	X
circulating	X
survival	X