Detail

Chr	chr12
start	53962308
end	53974956
lncRNA name	HOTAIR
entrez id	100124700
hgnc id	HGNC:33510
ensg id	ENSG00000228630
refseq id	NR_003716
methods	Microarray, qPCR, Western blot
regulated	up-regulated
function description	overexpression of JMJD6 increased HOTAIR expression and JMJD6 siRNAs suppressed it in ER+ MCF-7, triple negative MDA-MB-231 and non-breast cancer HEK 293 cells.Therefore, JMJD6 regulates HOTAIR independent of ER status.We propose that high JMJD6 expression may achieve higher levels of HOTAIR in breast tumors. Further, since high levels of HOTAIR promote metastasis and death, blocking JMJD6 may be useful in preventing such events.
pubmed id	29229759
year	2018
title	JMJD6 induces HOTAIR, an oncogenic lincRNA, by physically interacting with its proximal promoter.
drug	X
circulating	X
survival	V