Detail

Chr	chr7
start	27198575
end	27207259
lncRNA name	HOTTIP
entrez id	100316868
hgnc id	HGNC:37461
ensg id	ENSG00000243766
refseq id	NR_037843
methods	qPCR, Western blot, in vitro knockdown, RNAi
regulated	up-regulated
function description	Using gain-and-loss-of experiments in vitro and in vivo, we observed the marked upregulation of HOTTIP/HOXA11 in the breast cancer cell line, MCF-7, and the downregulation of HOTTIP or HOXA11, which might inhibit cell proliferation and migration but promote cell apoptosis in breast cancer MCF-7 cells. In addition, by further rescue experiments with HOXA11 overexpression, we uncovered a novel potential regulatory mechanism between HOTTIP and one of its physical HOXA clusters, HOXA11. Hence, HOTTIP may mediate, at least partly, HOXA11 expression involved in cell growth, migration, and apoptosis of breast cancer MCF-7 cells.
pubmed id	29415429
year	2018
title	LncRNA HOTTIP-Mediated HOXA11 Expression Promotes Cell Growth, Migration and Inhibits Cell Apoptosis in Breast Cancer.
drug	X
circulating	X
survival	X