Detail

Chr	chr15
start	98645863
end	98651221
lncRNA name	IRAIN
entrez id	104472848
hgnc id	HGNC:50365
ensg id	NA
refseq id	NR_126453
methods	qPCR etc.
regulated	down-regulated
function description	In breast cancer tissues, we found that IRAIN lncRNA was transcribed from an intronic promoter in an antisense diretcion as compared to the IGF1R coding mRNA. Unlike the IGF1R coding RNA, this non-coding RNA was imprinted, with monoallelic expression from the paternal allele. IRAIN was aberrantly imprinted in both tumours and peripheral blood leucocytes, exhibiting a pattern of allele-switch: the allele expressed in normal tissues was inactivated and the normally imprinted allele was expressed.
pubmed id	25465188
year	2014
title	Aberrant allele-switch imprinting of a novel IGF1R intragenic antisense non-coding RNA in breast cancers.
drug	X
circulating	V
survival	X