Detail

Chr	chr15
start	87576929
end	87579866
lncRNA name	LINC00052
entrez id	145978
hgnc id	HGNC:26455
ensg id	ENSG00000259527
refseq id	NR_026869
methods	microarray, qPCR, RNAi, Western blot, ISH etc.
regulated	up-regulated
function description	Gene silencing of LINC00052 diminished both LINC00052 and HER3 expression and reduced cancer cell growth in vitro and in vivo. LINC00052 overexpression promoted cancer cell growth in vitro and in vivo and increased HER3-mediated downstream signaling. Importantly, neutralization of HER3 signaling with HER3 targeting monoclonal antibodies blocked LINC00052 mediated cancer cell proliferation in vitro and tumor growth in vivo, suggesting LINC00052 promoting cancer growth through HER3 signaling.
pubmed id	28036286
year	2017
title	HER3 and LINC00052 interplay promotes tumor growth in breast cancer
drug	X
circulating	X
survival	X