Detail

Chr	chr2
start	87454781
end	87636740
lncRNA name	LINC00152
entrez id	112597
hgnc id	HGNC:28717
ensg id	ENSG00000222041
refseq id	NR_024204
methods	qPCR, Western blot
regulated	up-regulated
function description	linc00152 was highly expressed in all basal-like cell lines and in the majority of TNBC tissues. Linc00152 suppression by shRNA significantly inhibited invasion and colony growth. Such suppression also triggered apoptosis in vitro and inhibited tumor growth in vivo.linc00152 partially enhanced breast cancer tumorigenesis by inactivation of the BRCA1/PTEN through DNA methyltransferases.linc00152 as a promising biomarker and therapeutic target for human TNBC treatment.
pubmed id	29156515
year	2017
title	Linc00152 promotes tumorigenesis by regulating DNMTs in triple-negative breast cancer.
drug	X
circulating	X
survival	X