Detail

Chr	chr10
start	4650185
end	4678154
lncRNA name	LINC00704
entrez id	NA
hgnc id	NA
ensg id	ENSG00000231298
refseq id	NA
methods	RNA-seq, Western blot, in vitro knockdown etc.
regulated	up-regulated
function description	MANCR (mitotically-associated long noncoding RNA; LINC00704), which is upregulated in breast cancer patient specimens and cells. Depletion of MANCR in triple-negative breast cancer cells significantly decreases cell proliferation and viability, with concomitant increases in DNA damage. MANCR expression is highest in mitotic cells by both RT-qPCR and RNA in situ hybridization. Consistent with a role in cell-cycle regulation, MANCR-depleted cells have a lower mitotic index and higher incidences of defective cytokinesis and cell death.MANCR, in genomic stability of aggressive breast cancer, and identify it as a potential therapeutic target
pubmed id	29378907
year	218
title	Mitotically-Associated lncRNA (MANCR) Affects Genomic Stability and Cell Division in Aggressive Breast Cancer.
drug	V
circulating	X
survival	V