Detail

Chr	chr12
start	121795267
end	121803906
lncRNA name	LINC01089
entrez id	338799
hgnc id	HGNC:27886
ensg id	ENSG00000212694
refseq id	NR_002809
methods	microarray, qPCR, RNAi, Cell migration and invasion assay etc.
regulated	down-regulated
function description	Functional analyses of this group uncovered LINC01089 (here renamed LncRNA Inhibiting Metastasis; LIMT), a highly conserved lncRNA, which is depleted in basal-like and in HER2-positive tumors, and the low expression of which predicts poor patient prognosis. Interestingly, EGF rapidly downregulates LIMT expression by enhancing histone deacetylation at the respective promoter. We also find that LIMT inhibits extracellular matrix invasion of mammary cells in vitro and tumor metastasis in vivo.
pubmed id	27485121
year	2016
title	LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer.
drug	X
circulating	X
survival	V