Detail

Chr	chr10
start	6737382
end	6739026
lncRNA name	LINP1
entrez id	108570035
hgnc id	HGNC:53170
ensg id	ENSG00000223784
refseq id	NR_138480
methods	qPCR, RNAi, Western blot, Northern blot, RIP, RNA pull-down assay etc.
regulated	up-regulated
function description	LINP1, which is overexpressed in human triple-negative breast cancer. We found that LINP1 enhances repair of DNA double-strand breaks by serving as a scaffold linking Ku80 and DNA-PKcs, thereby coordinating the NHEJ pathway. Importantly, blocking LINP1, which is regulated by p53 and epidermal growth factor receptor (EGFR) signaling, increases the sensitivity of the tumor-cell response to radiotherapy in breast cancer.
pubmed id	27111890
year	2016
title	Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer.
drug	X
circulating	X
survival	X