Detail

Chr	chr11
start	65497688
end	65506516
lncRNA name	MALAT1
entrez id	378938
hgnc id	HGNC:29665
ensg id	ENSG00000251562
refseq id	NR_002819
methods	qPCR, RNAi, Flow cytometry assay, MTT assay etc.
regulated	up-regulated
function description	Results showed that MALAT1 expression was significantly up-regulated in 85.9% (67/78) of cancerous tissues compared with normal counterparts. Further, an elevated MALAT1 expression in BC tissue was significantly associated with lymph metastasis and adverse 5-year disease-free survival. Suppression of lncRNA MALAT1 significantly inhibited BC cells proliferation, migration and invasion, induced apoptosis and cell cycle G1 arrest. In addition, serum MALAT1 levels in BC patients were much higher than levels in patients with benign breast disease.
pubmed id	27466303
year	2016
title	Clinical Significance of Long Non-coding RNA MALAT1 Expression in Tissue and Serum of Breast Cancer.
drug	X
circulating	V
survival	V