Detail

Chr	chr11
start	65497688
end	65506516
lncRNA name	MALAT1
entrez id	378938
hgnc id	HGNC:29665
ensg id	ENSG00000251562
refseq id	NR_002819
methods	qPCR, Western blot, RIP, ChIP etc.
regulated	differential expression
function description	oncogenic splicing factor SRSF1 bridges MALAT1 to mutant p53 and ID4 proteins in breast cancer cells. Mutant p53 and ID4 delocalize MALAT1 from nuclear speckles and favor its association with chromatin. This enables aberrant recruitment of MALAT1 on VEGFA pre-mRNA and modulation of VEGFA isoforms expression. VEGFA-dependent expression signatures associate with ID4 expression specifically in basal-like breast cancers carrying TP53 mutations. To evaluate the prognostic value of the signatures, we estimated the patients' survival probability using the Kaplan��CMeier method. Serum-free media with or without recombinant VEGFA were used as controls.
pubmed id	28652379
year	2017
title	The mutant p53-ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1.
drug	X
circulating	X
survival	V