Detail

Chr	chr11
start	65497688
end	65506516
lncRNA name	MALAT1
entrez id	378938
hgnc id	HGNC:29665
ensg id	ENSG00000251562
refseq id	NR_002819
methods	qRT-PCR
regulated	up-regulated
function description	all three tagging SNPs (rs3200401, rs619586 and rs7927113) in lncRNA MALAT1 were selected for genotyping in 487BCE patients and 489 cancer-free controls in Chinese Han population, and futher experiment of quantitative real-time (qRT) PCR was conducted to examine the relative expression of MALAT1. The results showed that individuals with genotype AG of rs619586 has a decreased risk of BC in codominant model (OR: 0.684, 95%CI: 0.478-0.979), dominant mode (OR: 0.675, 95%CI: 0.479-0.951) and over-dominant model (OR: 0.692, 95%CI: 0484-0.989). Also, qRT-PCR results revealed that the expression for MALAT1 with AG (0.827??0.490), GG (0.511??0.149) and AG+GG genotypes (0.743??0.447) of rs619586 was significantly lower than that with genotype AA (1.511??0.737).
pubmed id	29146194
year	2018
title	Association analyses of genetic variants in long non-coding RNA MALAT1 with breast cancer susceptibility and mRNA expression of MALAT1 in Chinese Han population.
drug	X
circulating	V
survival	X