Detail

Chr	chr14
start	100779410
end	100861031
lncRNA name	MEG3
entrez id	55384
hgnc id	HGNC:14575
ensg id	ENSG00000214548
refseq id	NR_002766
methods	ChIP, Flow cytometry assay, Cell proliferation assay etc.
regulated	down-regulated
function description	we identified the expressing difference of several tumor-related lncRNAs in breast cancer samples and found that, MEG3, which is downregulated in non-small cell lung cancer (NSCLC) tumor tissues, is also downregulated in breast cancer samples compared with adjacent tissues. For figuring out the effect of MEG3 in breast cancer cells MCF7 and MB231, we overexpressed MEG3 in these cells, and found that it resulted the inhibition of proliferation, colony formation, migration and invasion capacities by enhancing p53's transcriptional activity on its target genes, including p21, Maspin and KAI1. MEG3 presented similar effects in MB157, which is a p53-null breast cancer cell line, when functional p53 but not p53R273H mutant, which lacks transcriptional activity, was introduced.
pubmed id	27166155
year	2016
title	Downregulated long non-coding RNA MEG3 in breast cancer regulates proliferation, migration and invasion by depending on p53's transcriptional activity
drug	X
circulating	X
survival	X