Detail

Chr	chr22
start	26646428
end	26676475
lncRNA name	MIAT
entrez id	440823
hgnc id	HGNC:33425
ensg id	ENSG00000225783
refseq id	NR_003491
methods	qPCR, Western blot, in vitro knockdown, RNAi
regulated	up-regulated
function description	MIAT expression was much higher in high-grade tumors compared to low-grade ones. Unlike P53 positive tumors, MIAT expression was upregulated in ER, PR, Her2 positive tumor tissues. An increase in the expression of mir-302, mir-150, and a decrease in the expression of mir-29c were detected following MIAT silencing. More importantly, knockdown MIAT significantly elevated the expression of p16Ink4A and Cox2, which commitment cellular senescence in breast cancer cells.
pubmed id	29345338
year	2018
title	MIAT lncRNA is overexpressed in breast cancer and its inhibition triggers senescence and G1 arrest in MCF7 cell line.
drug	X
circulating	X
survival	X