Detail

Chr	chr6
start	22134957
end	22147193
lncRNA name	NBAT1
entrez id	729177
hgnc id	HGNC:49075
ensg id	ENSG00000260455
refseq id	NR_034143
methods	microarray, qPCR, Western blot, RIP, ChIP etc.
regulated	down-regulated
function description	Here, we report that NBAT1 is down-regulated in various types of cancer. Particularly, reduced NBAT1 in breast cancer is associated with tumor metastasis and poor patient prognosis. In vitro, ectopic NBAT1 inhibits migration and invasion of breast cancer cells. Mechanistic study shows that NBAT1 is associated with PRC2 member EZH2 and regulates global gene expression profile. Among them, DKK1 (dickkopf WNT signaling pathway inhibitor 1) is found to be regulated by NBAT1 in a PRC2 dependent manner, and is responsible for NBAT1's effects in inhibiting migration and invasion of breast cancer cells.
pubmed id	26378045
year	2015
title	NBAT1 suppresses breast cancer metastasis by regulating DKK1 via PRC2.
drug	X
circulating	X
survival	V