Detail

Chr	chr20
start	57710183
end	57712780
lncRNA name	NKILA
entrez id	105416157
hgnc id	HGNC:51599
ensg id	ENSG00000278709
refseq id	NR_131157
methods	qPCR, RNAi, RIP etc.
regulated	down-regulated
function description	Importantly, NKILA is essential to prevent over-activation of NF-?eB pathway in inflammation-stimulated breast epithelial cells. Furthermore, low NKILA expression is associated with breast cancer metastasis and poor patient prognosis. Therefore, lncRNAs can directly interact with functional domains of signaling proteins, serving as a class of NF-?eB modulators to suppress cancer metastasis.
pubmed id	25759022
year	2015
title	A Cytoplasmic NF-?eB Interacting Long Noncoding RNA Blocks I?eB Phosphorylation and Suppresses Breast Cancer Metastasis.
drug	X
circulating	X
survival	V