Detail

Chr	chr20
start	57710183
end	57712780
lncRNA name	NKILA
entrez id	105416157
hgnc id	HGNC:51599
ensg id	ENSG00000278709
refseq id	NR_131157
methods	qPCR, Western blot etc.
regulated	up-regulated
function description	In this study, we found that TGF-B activates the NF-kB pathway. Inhibition of NF-kB signaling markedly abrogates TGF-B-induced EMT. By studying the regulatory mechanism of TGF-B-induced NF-kB signaling, we found that lncRNA NKILA was upregulated by TGF-B and was essential for the negative feedback regulation of the NF-kB pathway. Accordingly, overexpression of NKILA significantly reduced TGF-B-induced tumor metastasis in vivo. Consistent with the results from mice, the expression of NKILA was negatively correlated with EMT phenotypes in clinical breast cancer samples. Collectively, our study findings indicated that the NKILA-mediated negative feedback affects TGF-B-induced NF-kB activation and that NKILA may be a therapeutic molecule in breast cancer metastasis via inhibition of EMT.
pubmed id	29761481
year	2018
title	LncRNA NKILA Suppresses TGF-B-induced Epithelial-Mesenchymal Transition by Blocking NF-kB Signaling in Breast Cancer.
drug	X
circulating	X
survival	V