Detail

Chr	NA
start	NA
end	NA
lncRNA name	PARTICLE
entrez id	100630918
hgnc id	HGNC:50886
ensg id	NA
refseq id	NR_038942
methods	qPCR, RNAi etc.
regulated	differential expression
function description	In silico analysis identified additional regions for PARTICLE triplexes at >1600 genomic locations. Multiple PARTICLE triplexes are clustered predominantly within the human and mouse tumor suppressor WW Domain Containing Oxidoreductase (WWOX) gene. Surface plasmon resonance diffraction and electrophoretic mobility shift assays were consistent with PARTICLE triplex formation within human WWOX with high resolution imaging demonstrating its enrichment at this locus on chromosome 16. PARTICLE knockdown and over-expression resulted in inverse changes in WWOX transcripts levels with siRNA interference eliminating PARTICLEs elevated transcription to irradiation. The evidence for a second functional site of PARTICLE triplex formation at WWOX suggests that PARTICLE may form triplex-mediated interactions at multiple positions in the human genome including remote loci.
pubmed id	28769061
year	2017
title	PARTICLE triplexes cluster in the tumor suppressor WWOX and may extend throughout the human genome.
drug	X
circulating	V
survival	V