Detail

Chr	chr8
start	127794533
end	128101253
lncRNA name	PVT1
entrez id	5820
hgnc id	HGNC:9709
ensg id	ENSG00000249859
refseq id	NR_003367
methods	qPCR, Western blotting etc.
regulated	up-regulated
function description	PVT1 expression is upregulated in human breast cancer tissues and cell lines.And the elevation of PVT1 was correlated with poor prognosis in breast cancer patients. We also identified an interaction between SOX2 and PVT1, which promotes breast cancer growth and invasion through epithelial to mesenchymal transition. To further reveal the function of SOX2/ PVT1 in breast cancer, the MTT and invasion assay were performed through silencing of PVT1 or SOX2. We found that either knockdown PVT1 or blocking SOX2 can suppress breast cancer cell growth and invasion through inhibition of EMT.
pubmed id	28882595
year	2017
title	Upregulation of SOX2 activated LncRNA PVT1 expression promotes breast cancer cell growth and invasion
drug	X
circulating	X
survival	V