Detail

Chr	chr8
start	127794533
end	128101253
lncRNA name	PVT1
entrez id	5820
hgnc id	HGNC:9709
ensg id	ENSG00000249859
refseq id	NR_003367
methods	qPCR, Western blot, RIP etc.
regulated	up-regulated
function description	Here we report that the lncRNA PVT1 promotes KLF5/beta-catenin signaling to drive TNBC tumorigenesis. PVT1 is upregulated in clinical TNBC tumors. Using genetic approaches targeting PVT1 in TNBC cells, we found that PVT1 depletion inhibited cell proliferation, colony formation, and orthotopic xenograft tumor growth. Mechanistically, PVT1 binds with KLF5 and increases its stability via BAP1, which upregulates beta-catenin signaling, resulting in enhanced TNBC tumorigenesis. PVT1, KLF5, and beta-catenin were also revealed to be co-expressed in clinical TNBC samples. Our findings uncover a new singaling pathway to mediate TNBC, and provide PVT1 as a new target for improving treatment of TNBC.
pubmed id	29760406
year	2018
title	LncRNA PVT1 regulates triple-negative breast cancer through KLF5/beta-catenin signaling.
drug	X
circulating	X
survival	V