Detail

Chr	chr1
start	28578538
end	28582983
lncRNA name	SNHG12
entrez id	85028
hgnc id	HGNC:30062
ensg id	ENSG00000197989
refseq id	NR_024127
methods	qPCR, RNAi, Western blot, ChIP, Luciferase reporter assay, Cell proliferation assay etc.
regulated	up-regulated
function description	SNHG12 is upregulated in TNBC. Mechanistic investigations show that SNHG12 is a direct transcriptional target of c-MYC. Silencing SNHG12 expression inhibits TNBC cells proliferation and apoptosis promotion, whereas SNHG12 overexpression has the opposite effect. In addition, we reveal that SNHG12 may promote cells migration by regulating MMP13 expression.
pubmed id	28337281
year	2017
title	C-MYC-induced upregulation of lncRNA SNHG12 regulates cell proliferation, apoptosis and migration in triple-negative breast cancer.
drug	X
circulating	X
survival	V