Detail

Chr	chr19
start	5558167
end	5578349
lncRNA name	TINCR
entrez id	NA
hgnc id	NA
ensg id	ENSG00000223573
refseq id	NA
methods	qPCR, Luciferase reporter assay, in vitro knockdown etc.
regulated	up-regulated
function description	TINCR was aberrantly up-regulated by SP1,which in turn stimulated cell proliferation,anchorage-independent growth and suppressed cell apoptosis in breast cancer.TINCR silencing significantly suppressed migration and invasion in vitro and xenograft tumor growth in vivo.Mechanistically, TINCR modulated KLF4 expression via competing with miR-7, which consequently contributed to its oncogenic potential.MiR-7 inhibition severely compromised TINCR silencing-elicited tumor repressive effects
pubmed id	29614984
year	2018
title	Up-regulation of ceRNA TINCR by SP1 contributes to tumorigenesis in breast cancer.
drug	X
circulating	V
survival	V