Detail

Chr	chr20
start	50040716
end	50041504
lncRNA name	TRERNA1
entrez id	100887755
hgnc id	HGNC:44307
ensg id	ENSG00000231265
refseq id	NR_051976
methods	qPCR, Lentiviral infection, Luciferase reporter assay, RNA pull-down assay, Cell proliferation assay etc.
regulated	up-regulated
function description	We found that treRNA is upregulated in paired clinical breast cancer primary and lymph-node metastasis samples, and that its expression stimulates tumour invasion in vitro and metastasis in vivo. Interestingly, we found that treRNA downregulates the expression of the epithelial marker E-cadherin by suppressing the translation of its mRNA. We identified a novel ribonucleoprotein (RNP) complex, consisting of RNA-binding proteins (hnRNP K, FXR1, and FXR2), PUF60 and SF3B3, that is required for this treRNA functions. Translational suppression by treRNA is dependent on the 3'UTR of the E-cadherin mRNA. Taken together, our study indicates a novel mechanism of gene regulation by lncRNAs in cancer progression.
pubmed id	23974796
year	2013
title	Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step.
drug	X
circulating	X
survival	X