Detail

Chr	chr22
start	30969245
end	30979395
lncRNA name	TUG1
entrez id	55000
hgnc id	HGNC:26066
ensg id	ENSG00000253352
refseq id	NR_002323
methods	qPCR, RNAi, Cell proliferation assay etc.
regulated	up-regulated
function description	The expression of TUG1 was enhanced in breast cancerous tissues and in highly invasive breast cancer cell lines and was associated with clinical variables, including tumor size, distant metastasis and TNM staging. Knockdown of TUG1 significantly slowed down cell proliferation, cell migration, and invasion in breast cancer cell lines MDA-MB-231 and MDA-MB-436. In addition, cell apoptotic rate was shown to increase upon siTUG1 treatment as evidenced by increases of the activities of caspase-3 and caspase-9.
pubmed id	27848085
year	2016
title	Long non-coding RNA TUG1 promotes cell proliferation and metastasis in human breast cancer.
drug	X
circulating	X
survival	X