Detail

Chr	chr22
start	30969245
end	30979395
lncRNA name	TUG1
entrez id	55000
hgnc id	HGNC:26066
ensg id	ENSG00000253352
refseq id	NR_002323
methods	qPCR, Western blot, Luciferase reporter assay, Flow cytometry assay, MTT assay etc.
regulated	up-regulated
function description	Higher expression of TUG1 was observed in breast cancer tissues and cell lines than in the corresponding controls. TUG1 knockdown reduced proliferation, suppressed cell cycle progression, and promoted apoptosis of MCF-7 cells. The dual luciferase reporter assay showed that TUG1 could negatively regulate the expression of miR-9. MiR-9 inhibition abrogated the effect of TUG1 knockdown on the proliferation, cell cycle progression, and apoptosis of MCF-7 cells. TUG1 positively regulated the expression of MTHFD2 in breast cancer cells.
pubmed id	28053623
year	2016
title	LncRNA Taurine-Upregulated Gene 1 Promotes Cell Proliferation by Inhibiting MicroRNA-9 in MCF-7 Cells.
drug	X
circulating	X
survival	X